HIBISCUS: Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome
Identifieur interne : 000B82 ( Main/Exploration ); précédent : 000B81; suivant : 000B83HIBISCUS: Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome
Auteurs : Cristina Belizna [France] ; Francesca Pregnolato [Italie] ; Sébastien Abad [France] ; Jaume Alijotas-Reig [Espagne] ; Howard Amital [Israël] ; Zahir Amoura [France] ; Laura Andreoli [Italie] ; Emmanuel Andres [France] ; Achile Aouba [France] ; Sule Apras Bilgen [Turquie] ; Laurent Arnaud [France] ; Boris Bienvenu [France] ; Viktoria Bitsadze [Russie] ; Patrick Blanco [France] ; Miri Blank [Israël] ; Maria Borghi [Italie] ; Antonia Caligaro [Italie] ; Elisabeta Candrea [Roumanie] ; Valentina Canti [Italie] ; Laurent Chiche [France] ; Jean Chrétien [France] ; Jan Willem Cohen Tervaert [Pays-Bas] ; Laura Damian [Roumanie] ; Teresa Delross [Italie] ; Emmanuelle Dernis [France] ; Katrien Devreese [Belgique] ; Aleksandra Djokovic [Serbie] ; Enrique Esteve-Valverde [Espagne] ; Maria Favaro [Italie] ; Céline Fassot [France] ; Raquel Ferrer-Oliveras [Espagne] ; Alban Godon [France] ; Mohamed Hamidou [France] ; Milena Hasan [France] ; Daniel Henrion [France] ; Bernard Imbert [France] ; Pierre Yves Jeandel [France] ; Pascale Jeannin [France] ; Patrick Jego [France] ; Noemie Jourde-Chiche [France] ; Jamilya Khizroeva [Russie] ; Olivier Lambotte [France] ; Cédric Landron [France] ; Jose Omar Latino [Argentine] ; Estibaliz Lazaro [France] ; Karina De Leeuw [Pays-Bas] ; Thomas Le Gallou [France] ; Levent Kiliç [Turquie] ; Maarten Limper [Pays-Bas] ; Laurent Loufrani [France] ; Romain Lubin [France] ; Nadine Magy-Bertrand [France] ; Guillaume Mahé [France] ; Alexander Makatsariya [Russie] ; Thierry Martin [France] ; Christian Muchardt [France] ; Gyorgy Nagy ; Loukman Omarjee [France] ; Pieter Van Paasen [Hongrie] ; Gilles Pernod [France] ; Florence Perrinet ; Gilberto Pïres Rosa [Portugal] ; Marc Antoine Pistorius [France] ; Amelia Ruffatti [Italie] ; Fatma Said [Tunisie] ; Patrick Saulnier [France] ; Damien Sene [France] ; Loïc Sentilhes [France] ; Ova Shovman [Israël] ; Jean Sibilia [France] ; Crina Sinescu [Roumanie] ; Natasa Stanisavljevic [Serbie] ; Ljudmila Stojanovich [Serbie] ; Lai Shan Tam [République populaire de Chine] ; Angela Tincani [Italie] ; Fréderic Tollis [France] ; Sebastian Udry [Argentine] ; Marie Noelle Ungeheuer [France] ; Mathilde Versini [France] ; Ricard Cervera [Espagne] ; Pier Luigi Meroni [Italie]Source :
- Autoimmunity Reviews [ 1568-9972 ] ; 2018-12.
English descriptors
- mix :
Abstract
The relapse rate in antiphospholipid syndrome (APS) remains high, i.e. around 20%–21% at 5 years in thrombotic APS and 20–28% in obstetrical APS [2, 3].Hydroxychloroquine (HCQ) appears as an additional therapy, as it possesses immunomodulatory and anti-thrombotic various effects [4–16].Our group recently obtained the orphan designation of HCQ in antiphospholipid syndrome by the European Medicine Agency.Furthermore, the leaders of the project made the proposal of an international project, HIBISCUS, about the use of Hydroxychloroquine in secondary prevention of obstetrical and thrombotic events in primary APS. This study has been launched in several countries and at now, 53 centers from 16 countries participate to this international trial.This trial consists in two parts: a retrospective and a prospective study.The French part of the trial in thrombosis has been granted by the French Minister of Health in December 2015 (the academic trial independent of the pharmaceutical industry PHRC N PAPIRUS) and is coordinated by one of the members of the leading consortium of HIBISCUS.
Url:
DOI: 10.1016/j.autrev.2018.05.012
Affiliations:
- Argentine, Belgique, Espagne, France, Hongrie, Israël, Italie, Pays-Bas, Portugal, Roumanie, Russie, République populaire de Chine, Serbie, Tunisie, Turquie
- Aquitaine, Auvergne-Rhône-Alpes, Catalogne, Nouvelle-Aquitaine, Pays de la Loire, Provence-Alpes-Côte d'Azur, Rhône-Alpes, Région Bretagne
- Angers, Barcelone, Bordeaux, Grenoble, Marseille, Rennes
- Université Grenoble-Alpes, Université Joseph Fourier, Université d'Aix-Marseille, Université d'Angers, Université de Barcelone, Université de Bordeaux, Université de Grenoble, Université de Rennes 1, Université européenne de Bretagne
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Le document en format XML
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type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-01936357</idno><idno type="halId">hal-01936357</idno><idno type="halUri">https://hal-univ-rennes1.archives-ouvertes.fr/hal-01936357</idno><idno type="url">https://hal-univ-rennes1.archives-ouvertes.fr/hal-01936357</idno><idno type="doi">10.1016/j.autrev.2018.05.012</idno><date when="2018-12">2018-12</date><idno type="wicri:Area/Hal/Corpus">000107</idno><idno type="wicri:Area/Hal/Curation">000107</idno><idno type="wicri:Area/Hal/Checkpoint">000022</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000022</idno><idno type="wicri:doubleKey">1568-9972:2018:Belizna C:hibiscus:hydroxychloroquine:for</idno><idno type="wicri:Area/Main/Merge">000B82</idno><idno type="wicri:Area/Main/Curation">000B82</idno><idno type="wicri:Area/Main/Exploration">000B82</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">HIBISCUS: Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome</title><author><name sortKey="Belizna, Cristina" sort="Belizna, Cristina" uniqKey="Belizna C" first="Cristina" last="Belizna">Cristina Belizna</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-151939" status="VALID"> <orgName>Centre Hospitalier Universitaire d'Angers</orgName> <orgName type="acronym">CHU Angers</orgName> <desc> <address> <addrLine>4 rue Larrey - 49933 Angers cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-angers.fr/</ref> </desc> <listRelation> <relation active="#struct-301358" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301358" type="direct"><org type="regroupinstitution" xml:id="struct-301358" status="OLD"> <idno type="IdRef">187401039</idno> <orgName>PRES Université Nantes Angers Le Mans</orgName> <orgName type="acronym">UNAM</orgName> <date type="start">2008-12-31</date> <date type="end">2016-01-01</date> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Pregnolato, Francesca" sort="Pregnolato, Francesca" uniqKey="Pregnolato F" first="Francesca" last="Pregnolato">Francesca Pregnolato</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-380289" status="VALID"> <orgName>Istituto di Ricovero e Cura a Carattere Scientifico</orgName> <orgName type="acronym">IRCCS</orgName> <desc> <address> <addrLine>Via Conte Ruggiero, 73, 94018 Troina EN</addrLine> <country key="IT"></country> </address> </desc> </hal:affiliation><country>Italie</country></affiliation></author><author><name sortKey="Abad, Sebastien" sort="Abad, Sebastien" uniqKey="Abad S" first="Sébastien" last="Abad">Sébastien Abad</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-15786" status="VALID"> <orgName>Université Paris 13</orgName> <orgName type="acronym">UP13</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris13.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Alijotas Reig, Jaume" sort="Alijotas Reig, Jaume" uniqKey="Alijotas Reig J" first="Jaume" last="Alijotas-Reig">Jaume Alijotas-Reig</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-410219" status="VALID"> <orgName>Vall d'Hebron University Hospital [Barcelona]</orgName> <desc> <address> <addrLine>C/ Natzaret, 115-11708035 Barcelona</addrLine> <country key="ES"></country> </address> <ref type="url">http://www.vhio.net/about-vhio/en_hospital-vall-hebron.php</ref> </desc> </hal:affiliation><country>Espagne</country></affiliation></author><author><name sortKey="Amital, Howard" sort="Amital, Howard" uniqKey="Amital H" first="Howard" last="Amital">Howard Amital</name><affiliation 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Box 39040, Tel Aviv 6997801</addrLine> <country key="IL"></country> </address> <ref type="url">http://english.tau.ac.il/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Israël</country></affiliation></author><author><name sortKey="Amoura, Zahir" sort="Amoura, Zahir" uniqKey="Amoura Z" first="Zahir" last="Amoura">Zahir Amoura</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-18474" status="VALID"> <orgName>Service de médecine interne [CHU Pitié-Salpétrière]</orgName> <desc> <address> <addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Andreoli, Laura" sort="Andreoli, Laura" uniqKey="Andreoli L" first="Laura" last="Andreoli">Laura Andreoli</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-446585" status="VALID"> <orgName>University of Brescia</orgName> <desc> <address> <addrLine>Piazza del Mercato, 15, Brescia BS, Italia</addrLine> <country key="IT"></country> </address> <ref type="url">http://www.unibs.it/</ref> </desc> </hal:affiliation><country>Italie</country></affiliation></author><author><name sortKey="Andres, Emmanuel" sort="Andres, Emmanuel" uniqKey="Andres E" first="Emmanuel" last="Andres">Emmanuel Andres</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300149" status="VALID"> <orgName>CHU Strasbourg</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Aouba, Achile" sort="Aouba, Achile" uniqKey="Aouba A" first="Achile" last="Aouba">Achile Aouba</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-7127" status="VALID"> <idno type="IdRef">026403064</idno> <idno type="ISNI">0000000121864076</idno> <orgName>Université de Caen Normandie</orgName> <orgName type="acronym">UNICAEN</orgName> <date type="start">1432-01-01</date> <desc> <address> <addrLine>Esplanade de la Paix - CS 14032 - 14032 CAEN Cedex 5</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.unicaen.fr/</ref> </desc> <listRelation> <relation active="#struct-455934" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-455934" type="direct"><org type="regroupinstitution" xml:id="struct-455934" status="VALID"> <idno type="IdRef">190906332</idno> <idno type="ISNI">0000000417859671 </idno> <orgName>Normandie Université</orgName> <orgName type="acronym">NU</orgName> <date type="start">2015-01-01</date> <desc> <address> <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.normandie-univ.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Apras Bilgen, Sule" sort="Apras Bilgen, Sule" uniqKey="Apras Bilgen S" first="Sule" last="Apras Bilgen">Sule Apras Bilgen</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-65505" status="VALID"> <orgName>Hacettepe University = Hacettepe Üniversitesi</orgName> <desc> <address> <addrLine>Hacettepe Üniversitesi Rektörlüğü Sıhhiye / ANKARA</addrLine> <country key="TR"></country> </address> <ref type="url">https://www.hacettepe.edu.tr/english/</ref> </desc> </hal:affiliation><country>Turquie</country></affiliation></author><author><name sortKey="Arnaud, Laurent" sort="Arnaud, Laurent" uniqKey="Arnaud L" first="Laurent" last="Arnaud">Laurent Arnaud</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300149" status="VALID"> <orgName>CHU Strasbourg</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Bienvenu, Boris" sort="Bienvenu, Boris" uniqKey="Bienvenu B" first="Boris" last="Bienvenu">Boris Bienvenu</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-311338" status="VALID"> <orgName>Hôpital Saint-Joseph [Marseille]</orgName> <date type="start">1919</date> <desc> <address> <addrLine>Hôpital Saint-Joseph26 Boulevard de Louvain, 13000 Marseille</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.hopital-saint-joseph.fr/index.php</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Bitsadze, Viktoria" sort="Bitsadze, Viktoria" uniqKey="Bitsadze V" first="Viktoria" last="Bitsadze">Viktoria Bitsadze</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-548801" status="INCOMING"> <orgName>Department of Obstetrics and Gynecology, I.M. 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Durand</orgName> <desc> <address> <addrLine>Buenos Aires</addrLine> <country key="AR"></country> </address> </desc> </hal:affiliation><country>Argentine</country></affiliation></author><author><name sortKey="Ungeheuer, Marie Noelle" sort="Ungeheuer, Marie Noelle" uniqKey="Ungeheuer M" first="Marie Noelle" last="Ungeheuer">Marie Noelle Ungeheuer</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-411827" status="VALID"> <orgName>Investigation Clinique et d’Accès aux Ressources Biologiques (Plate-forme) - Clinical Investigation and Access to BioResources</orgName> <orgName type="acronym">ICAReB</orgName> <desc> <address> <addrLine>Centre de Recherche Translationnelle - 25-28, rue du Docteur Roux - 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/en/team/biobanking-icareb/</ref> </desc> <listRelation> <relation active="#struct-300027" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno> <idno type="ISNI">0000 0001 2353 6535</idno> <orgName>Institut Pasteur [Paris]</orgName> <date type="start">1887-06-04</date> <desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Versini, Mathilde" sort="Versini, Mathilde" uniqKey="Versini M" first="Mathilde" last="Versini">Mathilde Versini</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-469997" status="VALID"> <orgName>Institut Arnault Tzanck</orgName> <desc> <address> <addrLine>Institut Arnaud Tzanck, Liver Unit, St. Laurent du Var, France</addrLine> <country key="FR"></country> </address> <ref type="url">http://saintlaurentduvar.tzanck.org/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Cervera, Ricard" sort="Cervera, Ricard" uniqKey="Cervera R" first="Ricard" last="Cervera">Ricard Cervera</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-125182" status="VALID"> <orgName>Barcelona Centre for International Health Research, Hospital Clinic</orgName> <orgName type="acronym">CRESIB</orgName> <desc> <address> <addrLine>Barcelona</addrLine> <country key="ES"></country> </address> </desc> <listRelation> <relation active="#struct-3447" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-3447" type="direct"><org type="institution" xml:id="struct-3447" status="VALID"> <orgName>Universitat de Barcelona</orgName> <orgName type="acronym">UB</orgName> <desc> <address> <addrLine>Gran Via de les Corts Catalanes, 585, 08007 Barcelona</addrLine> <country key="ES"></country> </address> <ref type="url">http://www.ub.edu/web/ub/en</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author><author><name sortKey="Meroni, Pier Luigi" sort="Meroni, Pier Luigi" uniqKey="Meroni P" first="Pier Luigi" last="Meroni">Pier Luigi Meroni</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-363961" status="VALID"> <orgName>Istituti di Ricovero e Cura a Carattere Scientifico </orgName> <orgName type="acronym">IRCCS</orgName> <desc> <address> <country key="IT"></country> </address> <ref type="url">http://www.salute.gov.it/portale/temi/p2_6.jsp?lingua=italiano&id=794&area=Ricerca%20sanitaria&menu=ssn</ref> </desc> </hal:affiliation><country>Italie</country></affiliation></author></analytic><idno type="DOI">10.1016/j.autrev.2018.05.012</idno><series><title level="j">Autoimmunity Reviews</title><idno type="ISSN">1568-9972</idno><imprint><date type="datePub">2018-12</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Antiphospholipid syndrome</term><term>Hydroxychloroquine</term><term>Primary antiphospholipid syndrome</term><term>Secondary prevention</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>The relapse rate in antiphospholipid syndrome (APS) remains high, i.e. around 20%–21% at 5 years in thrombotic APS and 20–28% in obstetrical APS [2, 3].Hydroxychloroquine (HCQ) appears as an additional therapy, as it possesses immunomodulatory and anti-thrombotic various effects [4–16].Our group recently obtained the orphan designation of HCQ in antiphospholipid syndrome by the European Medicine Agency.Furthermore, the leaders of the project made the proposal of an international project, HIBISCUS, about the use of Hydroxychloroquine in secondary prevention of obstetrical and thrombotic events in primary APS. This study has been launched in several countries and at now, 53 centers from 16 countries participate to this international trial.This trial consists in two parts: a retrospective and a prospective study.The French part of the trial in thrombosis has been granted by the French Minister of Health in December 2015 (the academic trial independent of the pharmaceutical industry PHRC N PAPIRUS) and is coordinated by one of the members of the leading consortium of HIBISCUS.</p> </div></front></TEI><affiliations><list><country><li>Argentine</li><li>Belgique</li><li>Espagne</li><li>France</li><li>Hongrie</li><li>Israël</li><li>Italie</li><li>Pays-Bas</li><li>Portugal</li><li>Roumanie</li><li>Russie</li><li>République populaire de Chine</li><li>Serbie</li><li>Tunisie</li><li>Turquie</li></country><region><li>Aquitaine</li><li>Auvergne-Rhône-Alpes</li><li>Catalogne</li><li>Nouvelle-Aquitaine</li><li>Pays de la Loire</li><li>Provence-Alpes-Côte d'Azur</li><li>Rhône-Alpes</li><li>Région Bretagne</li></region><settlement><li>Angers</li><li>Barcelone</li><li>Bordeaux</li><li>Grenoble</li><li>Marseille</li><li>Rennes</li></settlement><orgName><li>Université Grenoble-Alpes</li><li>Université Joseph Fourier</li><li>Université d'Aix-Marseille</li><li>Université d'Angers</li><li>Université de Barcelone</li><li>Université de Bordeaux</li><li>Université de Grenoble</li><li>Université de Rennes 1</li><li>Université européenne de Bretagne</li></orgName></list><tree><noCountry><name sortKey="Nagy, Gyorgy" sort="Nagy, Gyorgy" uniqKey="Nagy G" first="Gyorgy" last="Nagy">Gyorgy Nagy</name><name sortKey="Perrinet, Florence" sort="Perrinet, Florence" uniqKey="Perrinet F" first="Florence" last="Perrinet">Florence Perrinet</name></noCountry><country name="France"><noRegion><name sortKey="Belizna, Cristina" sort="Belizna, Cristina" uniqKey="Belizna C" first="Cristina" last="Belizna">Cristina Belizna</name></noRegion><name sortKey="Abad, Sebastien" sort="Abad, Sebastien" uniqKey="Abad S" first="Sébastien" last="Abad">Sébastien Abad</name><name sortKey="Amoura, Zahir" sort="Amoura, Zahir" uniqKey="Amoura Z" first="Zahir" last="Amoura">Zahir Amoura</name><name sortKey="Andres, Emmanuel" sort="Andres, Emmanuel" uniqKey="Andres E" first="Emmanuel" last="Andres">Emmanuel Andres</name><name sortKey="Aouba, Achile" sort="Aouba, Achile" uniqKey="Aouba A" first="Achile" last="Aouba">Achile Aouba</name><name sortKey="Arnaud, Laurent" sort="Arnaud, Laurent" uniqKey="Arnaud L" first="Laurent" last="Arnaud">Laurent Arnaud</name><name sortKey="Bienvenu, Boris" sort="Bienvenu, Boris" uniqKey="Bienvenu B" first="Boris" last="Bienvenu">Boris Bienvenu</name><name sortKey="Blanco, Patrick" sort="Blanco, Patrick" uniqKey="Blanco P" first="Patrick" last="Blanco">Patrick Blanco</name><name sortKey="Chiche, Laurent" sort="Chiche, Laurent" uniqKey="Chiche L" first="Laurent" last="Chiche">Laurent Chiche</name><name sortKey="Chretien, Jean" sort="Chretien, Jean" uniqKey="Chretien J" first="Jean" last="Chrétien">Jean Chrétien</name><name sortKey="Dernis, Emmanuelle" sort="Dernis, Emmanuelle" uniqKey="Dernis E" first="Emmanuelle" last="Dernis">Emmanuelle Dernis</name><name sortKey="Fassot, Celine" sort="Fassot, Celine" uniqKey="Fassot C" first="Céline" last="Fassot">Céline Fassot</name><name sortKey="Godon, Alban" sort="Godon, Alban" uniqKey="Godon A" first="Alban" last="Godon">Alban Godon</name><name sortKey="Hamidou, Mohamed" sort="Hamidou, Mohamed" uniqKey="Hamidou M" first="Mohamed" last="Hamidou">Mohamed Hamidou</name><name sortKey="Hasan, Milena" sort="Hasan, Milena" uniqKey="Hasan M" first="Milena" last="Hasan">Milena Hasan</name><name sortKey="Henrion, Daniel" sort="Henrion, Daniel" uniqKey="Henrion D" first="Daniel" last="Henrion">Daniel Henrion</name><name sortKey="Imbert, Bernard" sort="Imbert, Bernard" uniqKey="Imbert B" first="Bernard" last="Imbert">Bernard Imbert</name><name sortKey="Jeandel, Pierre Yves" sort="Jeandel, Pierre Yves" uniqKey="Jeandel P" first="Pierre Yves" last="Jeandel">Pierre Yves Jeandel</name><name sortKey="Jeannin, Pascale" sort="Jeannin, Pascale" uniqKey="Jeannin P" first="Pascale" last="Jeannin">Pascale Jeannin</name><name sortKey="Jego, Patrick" sort="Jego, Patrick" uniqKey="Jego P" first="Patrick" last="Jego">Patrick Jego</name><name sortKey="Jourde Chiche, Noemie" sort="Jourde Chiche, Noemie" uniqKey="Jourde Chiche N" first="Noemie" last="Jourde-Chiche">Noemie Jourde-Chiche</name><name sortKey="Lambotte, Olivier" sort="Lambotte, Olivier" uniqKey="Lambotte O" first="Olivier" last="Lambotte">Olivier Lambotte</name><name sortKey="Landron, Cedric" sort="Landron, Cedric" uniqKey="Landron C" first="Cédric" last="Landron">Cédric Landron</name><name sortKey="Lazaro, Estibaliz" sort="Lazaro, Estibaliz" uniqKey="Lazaro E" first="Estibaliz" last="Lazaro">Estibaliz Lazaro</name><name sortKey="Le Gallou, Thomas" sort="Le Gallou, Thomas" uniqKey="Le Gallou T" first="Thomas" last="Le Gallou">Thomas Le Gallou</name><name sortKey="Loufrani, Laurent" sort="Loufrani, Laurent" uniqKey="Loufrani L" first="Laurent" last="Loufrani">Laurent Loufrani</name><name sortKey="Lubin, Romain" sort="Lubin, Romain" uniqKey="Lubin R" first="Romain" last="Lubin">Romain Lubin</name><name sortKey="Magy Bertrand, Nadine" sort="Magy Bertrand, Nadine" uniqKey="Magy Bertrand N" first="Nadine" last="Magy-Bertrand">Nadine Magy-Bertrand</name><name sortKey="Mahe, Guillaume" sort="Mahe, Guillaume" uniqKey="Mahe G" first="Guillaume" last="Mahé">Guillaume Mahé</name><name sortKey="Martin, Thierry" sort="Martin, Thierry" uniqKey="Martin T" first="Thierry" last="Martin">Thierry Martin</name><name sortKey="Muchardt, Christian" sort="Muchardt, Christian" uniqKey="Muchardt C" first="Christian" last="Muchardt">Christian Muchardt</name><name sortKey="Omarjee, Loukman" sort="Omarjee, Loukman" uniqKey="Omarjee L" first="Loukman" last="Omarjee">Loukman Omarjee</name><name sortKey="Pernod, Gilles" sort="Pernod, Gilles" uniqKey="Pernod G" first="Gilles" last="Pernod">Gilles Pernod</name><name sortKey="Pistorius, Marc Antoine" sort="Pistorius, Marc Antoine" uniqKey="Pistorius M" first="Marc Antoine" last="Pistorius">Marc Antoine Pistorius</name><name sortKey="Saulnier, Patrick" sort="Saulnier, Patrick" uniqKey="Saulnier P" first="Patrick" last="Saulnier">Patrick Saulnier</name><name sortKey="Sene, Damien" sort="Sene, Damien" uniqKey="Sene D" first="Damien" last="Sene">Damien Sene</name><name sortKey="Sentilhes, Loic" sort="Sentilhes, Loic" uniqKey="Sentilhes L" first="Loïc" last="Sentilhes">Loïc Sentilhes</name><name sortKey="Sibilia, Jean" sort="Sibilia, Jean" uniqKey="Sibilia J" first="Jean" last="Sibilia">Jean Sibilia</name><name sortKey="Tollis, Frederic" sort="Tollis, Frederic" uniqKey="Tollis F" first="Fréderic" last="Tollis">Fréderic Tollis</name><name sortKey="Ungeheuer, Marie Noelle" sort="Ungeheuer, Marie Noelle" uniqKey="Ungeheuer M" first="Marie Noelle" last="Ungeheuer">Marie Noelle Ungeheuer</name><name sortKey="Versini, Mathilde" sort="Versini, Mathilde" uniqKey="Versini M" first="Mathilde" last="Versini">Mathilde Versini</name></country><country name="Italie"><noRegion><name sortKey="Pregnolato, Francesca" sort="Pregnolato, Francesca" uniqKey="Pregnolato F" first="Francesca" last="Pregnolato">Francesca Pregnolato</name></noRegion><name sortKey="Andreoli, Laura" sort="Andreoli, Laura" uniqKey="Andreoli L" first="Laura" last="Andreoli">Laura Andreoli</name><name sortKey="Borghi, Maria" sort="Borghi, Maria" uniqKey="Borghi M" first="Maria" last="Borghi">Maria Borghi</name><name sortKey="Caligaro, Antonia" sort="Caligaro, Antonia" uniqKey="Caligaro A" first="Antonia" last="Caligaro">Antonia Caligaro</name><name sortKey="Canti, Valentina" sort="Canti, Valentina" uniqKey="Canti V" first="Valentina" last="Canti">Valentina Canti</name><name sortKey="Delross, Teresa" sort="Delross, Teresa" uniqKey="Delross T" first="Teresa" last="Delross">Teresa Delross</name><name sortKey="Favaro, Maria" sort="Favaro, Maria" uniqKey="Favaro M" first="Maria" last="Favaro">Maria Favaro</name><name sortKey="Meroni, Pier Luigi" sort="Meroni, Pier Luigi" uniqKey="Meroni P" first="Pier Luigi" last="Meroni">Pier Luigi Meroni</name><name sortKey="Ruffatti, Amelia" sort="Ruffatti, Amelia" uniqKey="Ruffatti A" first="Amelia" last="Ruffatti">Amelia Ruffatti</name><name sortKey="Tincani, Angela" sort="Tincani, Angela" uniqKey="Tincani A" first="Angela" last="Tincani">Angela Tincani</name></country><country name="Espagne"><noRegion><name sortKey="Alijotas Reig, Jaume" sort="Alijotas Reig, Jaume" uniqKey="Alijotas Reig J" first="Jaume" last="Alijotas-Reig">Jaume Alijotas-Reig</name></noRegion><name sortKey="Cervera, Ricard" sort="Cervera, Ricard" uniqKey="Cervera R" first="Ricard" last="Cervera">Ricard Cervera</name><name sortKey="Esteve Valverde, Enrique" sort="Esteve Valverde, Enrique" uniqKey="Esteve Valverde E" first="Enrique" last="Esteve-Valverde">Enrique Esteve-Valverde</name><name sortKey="Ferrer Oliveras, Raquel" sort="Ferrer Oliveras, Raquel" uniqKey="Ferrer Oliveras R" first="Raquel" last="Ferrer-Oliveras">Raquel Ferrer-Oliveras</name></country><country name="Israël"><noRegion><name sortKey="Amital, Howard" sort="Amital, Howard" uniqKey="Amital H" first="Howard" last="Amital">Howard Amital</name></noRegion><name sortKey="Blank, Miri" sort="Blank, Miri" uniqKey="Blank M" first="Miri" last="Blank">Miri Blank</name><name sortKey="Shovman, Ova" sort="Shovman, Ova" uniqKey="Shovman O" first="Ova" last="Shovman">Ova Shovman</name></country><country name="Turquie"><noRegion><name sortKey="Apras Bilgen, Sule" sort="Apras Bilgen, Sule" uniqKey="Apras Bilgen S" first="Sule" last="Apras Bilgen">Sule Apras Bilgen</name></noRegion><name sortKey="Kilic, Levent" sort="Kilic, Levent" uniqKey="Kilic L" first="Levent" last="Kiliç">Levent Kiliç</name></country><country name="Russie"><noRegion><name sortKey="Bitsadze, Viktoria" sort="Bitsadze, Viktoria" uniqKey="Bitsadze V" first="Viktoria" last="Bitsadze">Viktoria Bitsadze</name></noRegion><name sortKey="Khizroeva, Jamilya" sort="Khizroeva, Jamilya" uniqKey="Khizroeva J" first="Jamilya" last="Khizroeva">Jamilya Khizroeva</name><name sortKey="Makatsariya, Alexander" sort="Makatsariya, Alexander" uniqKey="Makatsariya A" first="Alexander" last="Makatsariya">Alexander Makatsariya</name></country><country name="Roumanie"><noRegion><name sortKey="Candrea, Elisabeta" sort="Candrea, Elisabeta" uniqKey="Candrea E" first="Elisabeta" last="Candrea">Elisabeta Candrea</name></noRegion><name sortKey="Damian, Laura" sort="Damian, Laura" uniqKey="Damian L" first="Laura" last="Damian">Laura Damian</name><name sortKey="Sinescu, Crina" sort="Sinescu, Crina" uniqKey="Sinescu C" first="Crina" last="Sinescu">Crina Sinescu</name></country><country name="Pays-Bas"><noRegion><name sortKey="Cohen Tervaert, Jan Willem" sort="Cohen Tervaert, Jan Willem" uniqKey="Cohen Tervaert J" first="Jan Willem" last="Cohen Tervaert">Jan Willem Cohen Tervaert</name></noRegion><name sortKey="De Leeuw, Karina" sort="De Leeuw, Karina" uniqKey="De Leeuw K" first="Karina" last="De Leeuw">Karina De Leeuw</name><name sortKey="Limper, Maarten" sort="Limper, Maarten" uniqKey="Limper M" first="Maarten" last="Limper">Maarten Limper</name></country><country name="Belgique"><noRegion><name sortKey="Devreese, Katrien" sort="Devreese, Katrien" uniqKey="Devreese K" first="Katrien" last="Devreese">Katrien Devreese</name></noRegion></country><country name="Serbie"><noRegion><name sortKey="Djokovic, Aleksandra" sort="Djokovic, Aleksandra" uniqKey="Djokovic A" first="Aleksandra" last="Djokovic">Aleksandra Djokovic</name></noRegion><name sortKey="Stanisavljevic, Natasa" sort="Stanisavljevic, Natasa" uniqKey="Stanisavljevic N" first="Natasa" last="Stanisavljevic">Natasa Stanisavljevic</name><name sortKey="Stojanovich, Ljudmila" sort="Stojanovich, Ljudmila" uniqKey="Stojanovich L" first="Ljudmila" last="Stojanovich">Ljudmila Stojanovich</name></country><country name="Argentine"><noRegion><name sortKey="Latino, Jose Omar" sort="Latino, Jose Omar" uniqKey="Latino J" first="Jose Omar" last="Latino">Jose Omar Latino</name></noRegion><name sortKey="Udry, Sebastian" sort="Udry, Sebastian" uniqKey="Udry S" first="Sebastian" last="Udry">Sebastian Udry</name></country><country name="Hongrie"><noRegion><name sortKey="Van Paasen, Pieter" sort="Van Paasen, Pieter" uniqKey="Van Paasen P" first="Pieter" last="Van Paasen">Pieter Van Paasen</name></noRegion></country><country name="Portugal"><noRegion><name sortKey="Pires Rosa, Gilberto" sort="Pires Rosa, Gilberto" uniqKey="Pires Rosa G" first="Gilberto" last="Pïres Rosa">Gilberto Pïres Rosa</name></noRegion></country><country name="Tunisie"><noRegion><name sortKey="Said, Fatma" sort="Said, Fatma" uniqKey="Said F" first="Fatma" last="Said">Fatma Said</name></noRegion></country><country name="République populaire de Chine"><noRegion><name sortKey="Tam, Lai Shan" sort="Tam, Lai Shan" uniqKey="Tam L" first="Lai Shan" last="Tam">Lai Shan Tam</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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